24. COMT Gene Mutation: How to Supplement For Better Sleep and Reduced Anxiety | Ultimate Human Short with Gary Brecka

The Ultimate Human with Gary Brecka

Jan. 4, 2024

Get weekly tips from Gary Brecka on how to optimize your health and lifestyle routines - go to

For more info on Gary, please click here: 

Order The 1 Genetic Test That Will Give You Results For Life Here:


Get The Supplements That Gary Recommends Here:


Sign up for 10X Health Affiliate Program



Do you struggle with racing thoughts at bedtime, perfectionism, or sensitivity to sounds and textures? Gary Brecka and Sage Workinger discuss how a common genetic mutation called COMT can cause these issues and more. COMT, scientifically known as Catechol-O-methyltransferase, is known to cause estrogen imbalance and can lead to fatigue, anxiety, and a variety of other symptoms. Tune in to learn the exact supplements that helped Sage finally get a good night's sleep, feel less stressed, and how addressing this mutation could change your life, too!

00:45 - What is the COMT gene mutation? (Catechol-O-methyltransferase)

01:45 - How does COMT effect in your body?

02:30 - Sage Workinger talks about her personal struggle with the COMT mutation.

04:11 - What causes Obsessive Compulsive Disorder? ( OCD )

08:45 - Can COMT impact excess estrogen and stomach bloating?

15:30 - How to treat COMT.

16:15 - Why Sage avoids Green Tea.

18:00 - Recommended supplements for treating COMT. 

19:50 - What type of B-Vitamin helps the most?

Gary Brecka: @garybrecka

The Ultimate Human: @ultimatehumanpod

Subscribe on YouTube: @ultimatehumanpodcast

The Ultimate Human with Gary Brecka Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.

Learn more about your ad choices. Visit

This episode is from The Ultimate Human with Gary Brecka whose proprietor has full ownership and responsibility on its contents and artworks. It was shared using Castamatic, a podcast app for iPhone and iPad.