March 28, 2022

My guest is Dr. Andy Galpin, Professor of Kinesiology at California State University, Fullerton, and one of the foremost experts in the world on the science and application of methods to increase strength, hypertrophy and endurance performance. We discuss fundamental principles of strength and hypertrophy training and building endurance, the mechanisms underlying them and we review specific protocols to optimize training and recovery. We also discuss hydration, sleep, nutrition, supplements, and mental tools that can be leveraged to accelerate adaptations leading to enhanced strength, muscle growth and/or endurance.

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For the full show notes, visit


(00:00:00) Dr. Andy Galpin, Strength & Endurance Training  

(00:03:08) The Brain-Body Contract 

(00:03:55) AG1 (Athletic Greens), Thesis, InsideTracker

(00:08:20) Adaptations of Exercise, Progressive Overload 

(00:14:40) Modifiable Variables, One-Rep Max, Muscle Soreness

(00:27:30) Modifiable Variables of Strength Training, Supersets  

(00:43:50) How to Select Training Frequency: Strength vs. Hypertrophy 

(00:58:45) Hypertrophy Training, Repetition Ranges, Blood Flow Restriction 

(01:08:50) Tools: Protocols for Strength Training, the 3 by 5 Concept 

(01:10:48) Mind-Muscle Connection 

(01:16:16) Mental Awareness 

(01:27:57) Breathing Tools for Resistance Training & Post-Training 

(01:37:25) Endurance Training & Combining with Strength

(01:51:20) Tools: Protocols for Endurance Training

(02:08:15) Muscular Endurance, Fast vs. Slow Twitch Muscle 

(02:16:35) Hydration & the Galpin Equation, Sodium, Fasting   

(02:35:57) Cold Exposure & Training  

(02:43:15) Heat Exposure & Training 

(02:53:47) Recovery  

(03:04:02) Tool: Sodium Bicarbonate

(03:17:26) Tool: Creatine Monohydrate

(03:20:08) Absolute Rest

(03:29:08) Zero-Cost Support, YouTube Feedback, Spotify, Apple Reviews, Sponsors, Patreon, Thorne, Instagram, Twitter

Title Card Photo Credit: Mike Blabac


This episode is from Huberman Lab whose proprietor has full ownership and responsibility on its contents and artworks. It was shared using Castamatic, a podcast app for iPhone and iPad.